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Symbol Name ID |
Fcgr3
Fc receptor, IgG, low affinity III MGI:95500 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Increased circulating IgG level |
Decreased circulating antibody level |
Paraproteinemia |
Abnormality of blood and blood-forming tissues |
Abnormal bleeding |
Bleeding with minor or no trauma |
Epistaxis |
Gingival bleeding |
Gastrointestinal hemorrhage |
Hematemesis |
Melena |
Intracranial hemorrhage |
Intraventricular hemorrhage |
Joint hemorrhage |
Muscle hemorrhage |
Oral cavity bleeding |
Persistent bleeding after trauma |
Bruising susceptibility |
Purpura |
Petechiae |
Spontaneous hematomas |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Reduced erythrocyte adenylate kinase activity |
Reticulocytosis |
Anemia |
Hemolytic anemia |
Anemia of inadequate production |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Leukopenia |
Arterial thrombosis |
Thromboembolism |
Reduced factor VIII activity |
Prolonged partial thromboplastin time |
Abnormality of thrombocytes |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
Lymphoma |
Multiple myeloma |
Elevated erythrocyte sedimentation rate |
Splenic rupture |
Splenomegaly |
Hepatosplenomegaly |
| Disease(s) Associated with FCGR2A | |||||||||||||||||||||||||||||||||||||||||||||||||||
| autoimmune thrombocytopenic purpura | |||||||||||||||||||||||||||||||||||||||||||||||||||
| cystic fibrosis | |||||||||||||||||||||||||||||||||||||||||||||||||||
| factor VIII deficiency | |||||||||||||||||||||||||||||||||||||||||||||||||||
| hemolytic anemia | |||||||||||||||||||||||||||||||||||||||||||||||||||
| malaria | |||||||||||||||||||||||||||||||||||||||||||||||||||
| multiple myeloma | |||||||||||||||||||||||||||||||||||||||||||||||||||
| non-Hodgkin lymphoma | |||||||||||||||||||||||||||||||||||||||||||||||||||
| rheumatoid arthritis | |||||||||||||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus | |||||||||||||||||||||||||||||||||||||||||||||||||||
| temporal arteritis | |||||||||||||||||||||||||||||||||||||||||||||||||||
| thrombocytopenia | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Disease(s) Associated with FCGR2B | |||||||||||||||||||||||||||||||||||||||||||||||||||
| autoimmune thrombocytopenic purpura | |||||||||||||||||||||||||||||||||||||||||||||||||||
| malaria | |||||||||||||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Mouse Phenotypes | decreased B cell apoptosis |
decreased mast cell degranulation |
impaired macrophage phagocytosis |
enlarged spleen |
anemia |
decreased susceptibility to autoimmune hemolytic anemia |
increased neutrophil cell number |
abnormal leukocyte cell number |
increased germinal center B cell number |
abnormal mast cell physiology |
abnormal neutrophil physiology |
impaired neutrophil recruitment |
increased IgA level |
increased IgG1 level |
increased IgG2a level |
increased IgG2b level |
increased IgG3 level |
increased IgG level |
increased IgM level |
increased immunoglobulin level |
impaired natural killer cell mediated cytotoxicity |
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| Availability | Mouse Genotype | |||||||||||||||||||||
| Fcgr2btm1Ttk/Fcgr2btm1Ttk | ||||||||||||||||||||||
| Fcgr3tm1Jsv/Fcgr3tm1Jsv | ||||||||||||||||||||||
| Fcgr2btm1Kgcs/Fcgr2b+ | ||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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